Publications

Publications by Bayfield Lab Members:

Crosstalk between the tRNA methyltransferase Trm1 and RNA chaperone La influences eukaryotic tRNA maturation.  Porat, J., Vakiloroayaei, A., Remnant, B.M., Talebi, M., Cargill, T., Bayfield, M.A.  J. Biol. Chem. (2023) 299(11):105326. (Pubmed)

The LARP1 homolog Slr1p controls the stability and expression of proto-5’TOP mRNAs in fission yeast. Mansouri-Noori. F., Pircher, A., Bilodeau, D.,  Siniavskaia, L. Grigull, J., Rissland, O.S., Bayfield, M.A.  Cell Reports (2023) 42(10):113226. (Pubmed)

Heterogeneity in leukemia cells that escape drug-induced senescence-like state. Miller, D., Kerkhofs, K., Abbas-Aghababazadeh, F.,  Madahar, S.S., Minden, M.D., Hébert, J., Haibe-Kains, B., Bayfield, M.A., Benchimol, S. Cell Death & Disease (2023) 14(8):503. (Pubmed)

The fission yeast methyl phosphate capping enzyme Bmc1 guides 2′-O-methylation of the U6 snRNA. Porat, J., Slat, J.A., Rader, S.D., Bayfield, M.A. Nucleic Acids Research (2023) 51(16):8805-8819. (Pubmed)

Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila.  Kerkhofs K., Garg J., Fafard-Couture É., Abou Elela S., Scott M.S., Pearlman R.E., Bayfield M.A.  Nat Commun. 2022 Nov 28;13(1):7332. (Pubmed)

Porat J., El Baidouri M., Grigull J., Deragon J.M., Bayfield M.A.   The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.  Nat Commun. 2022 Mar 11;13(1):1277. (Pubmed)

Porat J., Kothe U., Bayfield M.A.   Revisiting tRNA chaperones: New players in an ancient game.  RNA.  2021 Feb 16;27(5):543-559. doi: 10.1261/rna.078428.120 (Pubmed)

Bayfield, M.A., Vinayak, J., Kerkhofs, K. and Mansouri-Noori, F.  La proteins couple use of sequence-specific and non-specific binding modes to engage RNA substrates. (2021) RNA Biol. Feb;18(2):168-177 (Pubmed)

Beenstock J., Ona S.M., Porat J., Orlicky S., Wan L.C.K., Ceccarelli D.F., Maisonneuve P., Szilard R.K., Yin Z., Setiaputra D., Mao D.Y.L., Khan M., Raval S., Schriemer D.C., Bayfield M.A., Durocher D., Sicheri F.  A substrate binding model for the KEOPS tRNA modifying complex.  Nat Commun. 2020 Dec 4;11(1):6233. doi: 10.1038/s41467-020-19990-5 (Pubmed)

Porat J. and Bayfield M.A.  Use of tRNA-Mediated Suppression to Assess RNA Chaperone Function. Methods Mol Biol. 2020;2106:107-120 (Pubmed)

Bayfield M.A., Kerkhofs K. and Mansouri-Noori F. C-lection by the DM15 Motif Gets LARP1 to the TOP. Structure. 2019 Dec 3;27(12):1737-1739 (Pubmed)

Marrella S.A., Brown K.A., Mansouri-Noori F., Porat J., Wilson D.J., Bayfield M.A. An interdomain bridge influences RNA binding of the human La protein. (2019) J Biol Chem. 294(5):1529-1540 (Pubmed)

Ehyai S., Miyake T., Williams D., Vinayak J., Bayfield M.A., McDermott J.C. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. (2018) EMBO Rep. pii: e45536. doi: 10.15252/embr.201745536 (Pubmed)

Vinayak, J., Marrella S.A., Hussain R.H., Rozenfeld L., Solomon K., Bayfield M.A. Human La binds mRNAs through contacts to the poly(A) tail. (2018) Nucleic Acids Research. 46(8):4228-4240 (Pubmed)

Vakiloroayaei, A., Shah, N.S., Oeffinger, M., Bayfield, M.A. The RNA chaperone La promotes pre-tRNA maturation via indiscriminate binding of both native and misfolded targets. (2017) Nucleic Acids Research. 45(19):11341-11355 (Pubmed)

Brown, K.A., Sharifi, S.,, Hussain, R., Donaldson, L., Bayfield, M.A., Wilson D.J.  Distinct dynamic modes enable the engagement of dissimilar ligands in a promiscuous atypical RNA Recognition Motif. (2016) Biochemistry. 55(51):7141-7150 (Pubmed)

Hussain, R.H., Zawawi, M., Bayfield, M.A.  Conservation of RNA chaperone activity of the human La related proteins 4, 6 and 7.  (2013) Nucleic Acids Research. 41(18):8715-25 (PubMed)

Naeeni A.R., Conte M.R., Bayfield M.A.  RNA chaperone activity of the human La protein is mediated by a variant RNA recognition motif.  (2012) J Biol Chem.  287(8):5472-82 PubMed.

Iben, J., Epstein, J., Bayfield, M.A., Bruinsma. M. W., Hasson, S., Bacikova, D., Ahmad, D., Rockwell D., Kittler, E. Zapp M., and Maraia, R. J. Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous S. pombe La mutants.   (2011)  Nucleic Acid Research. 39(11):4728-42 PubMed.

Bayfield, M.A., Yang, R. and Maraia, R.M. Conserved and divergent features of the structure and function of La and La-related proteins (LARPs). (2010) Biochim Biophys Acta. 1799: 365–378.  [PubMed]